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These overlapping limitations highlight an urgent need for further validation through large-scale, single-strain, long-term follow-up multicenter RCTs

Because of the retrospective nature of the study and the use of de-identified data, this study received an exemption waiver for approval and informed consent from the Institutional Review Board (IRB) of Chung Shan Medical University Hospital, identified by the reference number CS1-24047

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Generation of PI3KC2B KO and heterozygous mice showed that the mutation did not cause any morphological aberrations in the affected neurons, nor did it result in any prominent cortical dyslamination